GoDubai
  
  
  
  
Citylife > Press Release
  Home Contact us Add to Favourites
Most Recent Postings
More Press Releses
Featured Sections

Event Finder
A daily roundup of exhibitions, promotions and other events in Dubai and the rest of the Emirates.
Submit an Event
Latest Dubai Press Releases >> Healthcare and Medicine

 
  Share
The liver is the only solid organ that can regenerate itself in mammals, but what confers this special property to the liver has not been uncovered, despite decades of research.
● NYU Abu Dhabi researchers suggest that a novel mechanism driven by the epigenome promotes liver regeneration.
● The epigenome refers to the code that packages the DNA so that some parts can be activated (i.e. genes) and some parts remain in dormant domains - these dormant parts largely contain remnants of old viruses or transposable elements.
● Epigenetic compensation is when parts of the epigenome that usually have one role - i.e. to suppress genes, are co-opted to do a different job - when another part of the epigenome is missing modifications in the packaging material of the DNA influence how much a genetic program is active or repressed. These modifications do not change the DNA sequence, but instead, affect how cells read genes.
● This study reports that the primary role of the epigenome is to protect the genome against the activation of genomic parasites (transposable elements).
● The new findings have been published in the journal Developmental Cell.
 
Abu Dhabi, June 22, 2019:  In a recent study published in the journal Developmental Cell, NYU Abu Dhabi researchers have reported a new way in which the liver is primed to regenerate itself. They found that by stripping parts of the epigenome, which play a primary role in repressing “jumping genes” (i.e. transposable elements), other epigenetic marks were redistributed.
 
This newly discovered form of epigenetic compensation protects the genome against transposable elements activation, but takes these compensating epigenetic marks away from their normal job in regulating gene expression. The result is that when these marks are taken away from their normal role, the genes they usually repress are activated early and are sustained during the regenerative response to the surgical removal of part of the liver.
 
This type of surgery is relevant to humans, as it is used in resection of liver tumors and the regenerative response is essential for the liver to respond to damage. The findings are a significant advance in the understanding of the liver regeneration process, which is unique among the organs of humans, mice, and other mammals.
 
The researchers from NYU Abu Dhabi's Sadler Lab, led by Associate Professor of Biology Kirsten Sadler Edepli, removed a key epigenetic regulator, UHRF1 in the mouse liver. They found when they removed part of the liver, the remaining lobes responded more readily by activating pro-regenerative genes activated earlier, and this regeneration program stayed active longer, resulting in enhanced liver regeneration.
 
The epigenome refers to the code that packages the genome so that some parts can be activated (i.e. genes) and some parts remain in dormant domains - these dormant parts largely contain remnants of old viruses or transposable elements, which were made famous by the 1983 Nobel Prize discovery by Barbara McClintok.
 
Surprisingly, instead of causing massive activation of transposable elements or an immune response to mitigate the unleashing of transposable elements, as found in previous experiments, they discovered that there is an extra layer of protection by another repressive epigenetic mark (H3K27me3). This mark was redistributed from gene promoters to suppress transposable elements when DNA methylation was missing, thereby compensating for the loss of DNA methylation. When this mark is redistributed, it is removed from its role in repressing genes that promote liver regeneration. Thus, livers lacking UHRF1 are able to regenerate faster.
 
“When H3K27me3 compensates for the loss of DNA methylation, this results in a favorable epigenetic environment for liver regeneration,” said Sadler Edepli. “It will be exciting to explore whether drugs that can modify the epigenome have the potential to induce epigenetic compensation and increase the liver's ability to regenerate in cases of liver disease or failure.” Shuang Wang, a post-doctoral fellow in the Sadler Edepli laboratory who worked in her group at Icahn School of Medicine at Mount Sinai, led the study in collaboration with members of the lab at NYUAD as well as Emily Bernstein and Amaia Lujambio in NY.



Posted by : GoDubai Editorial Team
Viewed 11785 times
Posted on : Saturday, June 22, 2019  
Replication or redistribution in whole or in part is expressly prohibited without the prior written consent of GoDubai.com.
Previous Story : Ministry of Health & Prevention Unveils the Largest Expansion of Medical Examination Centers to Reac...
Next Story : RAK Hospital receives Superbrands Award for the fifth time
Email this article Print this article

Share this article with your friends and followers
NewsVine

Comments

Back to Top  
Most Viewed Press Release posted in the last 7 days
Chlo's Iconic Carlina Sunglasses In a Precious New Interpretation
Holiday Hair-Styling Essentials from VIERRO
Luxe Beauty Gifts for your Loved Ones this Festive Season
'Tis the Season to Be Glamorous - Beauty Essentials from GlamBeaute.com!
Your Holiday Gift Guide for Her
Homegrown Jewellery Brand Sumaya Bakkar Collections Curated Festive Gift List
New year, New You with Lunette
Uncovering the Beauty of Mechanics'
Free gold coins at Malabar Gold & Diamonds Festival.
Weather-proof your hair with HASK
Eberhard & Co. and the new Quadrifoglio Verde chronograph, dedicated to the p...
OMEGA Celebrates The New James Bond Watch in New York
The Real Secret to 10 Years Younger: Argan Face Oil
Berkan Steakhouse Launches in Dubai
Retrograde Fusion'
Dubai Festival City Mall Visitors In for A Jolly Festive Season Like No Other in...
Cole Haan Makes Its Debut at Sole Dxb 2019 Showcasing Footwear Collaborations
NYU Abu Dhabi Class of 2017 graduate Alioune Fall named as 2021 Schwarzman Scholar
Dubai Cares' Volunteers bring hope to children in remote village in Senegal
Emotional and highly dynamic: the design of the MINI John Cooper Works GP.
Customs World inks MoU with Indonesia to roll out World Logistics Passport
Best Menswear Items
Statement Cardigans
DP World joins forces with Dubai Cares in giving a new facelift to Umm Al Qura S...
GROHE received the Red Dot: Brand of the Year
Al Qemzi Claims Abu Dhabi Grand Prix Pole With Brilliant Surge
The Middle East Organic Market's Premiere Business Event Opens In Dubai
Reuben Kipyego and Vivian Kiplagat Win 2019 Adnoc Abu Dhabi Marathon
Set Up Stylish Outdoor Spaces with 2XL Furniture & Home Dcor
Hyundai's all-new 2020 Sonata now available in the UAE
Annual DIAC Conference examines impact of UAE Arbitration Law
Air Cargo Peak Season off to Slow Start, Annual Demand down 3.5% in October
Information City concludes "Al Saada" initiative
World Muslim Communities Council hosts first International Youth Forum in Abu Dhabi
Truesteam Technology by Lg is Setting A New Standard for Hygiene
Emiratis and expats set off to a two-week Camel Trek across the UAE desert
1247 Media joins du to offer free unlimited WiFi UAE data to RTA taxi users
Lewis Hamilton Tops Off Sixth World Title With Victory at Formula 1 Etihad Airwa...
Team Abu Dhabi's F2 world champion rounds off brilliant campaign with historic w...
Pre-school launches initiative encouraging children to stay hydrated
EASA extends Part 145 certification of SriLankan Engineering
Abu Dhabi Airports awards retail spaces at Midfield Terminal to Lulu Group
'Herman Miller and DIDI announce the winners of the Ergo Chair - Student Design...
ENEC welcomes visit by senior Emiratis to headquarters in Abu Dhabi
Give a cat a loving home
3rd Saudi Maritime Congress announced for March 2020
Abu Dhabi Digital Authority's TAMM' initiative awarded with the Sheikh Salem Al...
Dr Azad Moopen, Founder Chairman & MD, Aster DM Healthcare meets the Governor of...
Race Legend Back After Breaking Neck Sees More World Titles on the Way to Abu Dhabi