GoDubai
  
  
  
  
Citylife > Press Release
  Home Contact us Add to Favourites
Most Recent Postings
More Press Releses
Featured Sections

Event Finder
A daily roundup of exhibitions, promotions and other events in Dubai and the rest of the Emirates.
Submit an Event
Latest Dubai Press Releases >>

 
  Share

Changes within enamel cells point to mechanism by which excessive fluoride leads to Fluorosis

 

Abu Dhabi, UAE – April 7, 2020:  A team of researchers from NYU Abu Dhabi (NYUAD) and NYU College of Dentistry discovered a novel explanation for how dental fluorosis, a condition caused by overexposure to fluoride during childhood, arises. The researchers found that exposing teeth to excessive fluoride alters calcium signaling, mitochondrial function, and gene expression in the cells, forming tooth enamel.

The study, published in Science Signaling, was led by Associate Professor of Basic Science and Craniofacial Biology at NYU College of Dentistry Rodrigo Lacruz in collaboration with other researchers including NYUAD Assistant Professor of Biology Youssef Idaghdour, NYUAD Bioinformatician Vinu Manikandan, and NYUAD undergraduate student Ariya Chaloemtoem, among others.

To investigate the molecular bases of dental fluorosis, the researchers analyzed the effects of exposing tooth enamel cells to high levels of fluoride. Then, they assessed fluoride's impact on calcium signaling within the cells, given calcium's role in mineralizing tooth enamel. 

The researchers found that exposing enamel cells from rodents to fluoride resulted in calcium dysregulation, with decreases in calcium entering and stored in the endoplasmic reticulum, a compartment within cells with many functions, including storing calcium. In addition, fluoride disrupted the function of mitochondria (the cells' power generators), and therefore energy production was altered. Finally, RNA sequencing—which queries the functional output of genomes of cells—revealed that, in enamel cells exposed to fluoride, there was an increased expression of genes encoding endoplasmic reticulum stress response proteins and those encoding mitochondrial proteins, which are involved in producing the cell's energy. 

'Despite significant efforts in dental health education in the UAE, dental disease still remains a public health concern. Integrating physiology, genomics, and computational methods was instrumental in helping us demonstrate how too much fluoride alters enamel cell function and teeth development. NYUAD undergraduate student Ariya Chaloemtoem, who participated in computational analysis of the data, is currently pursuing this work to understand the effect of fluoride on other cell types,' Idaghdour said.

'Our research highlights how overexposure to fluoride can be detrimental to the teeth, especially in children when they are developing. Children should get the right amount of fluoride through a combination of fluoridated toothpaste and fluoridated water or supplements,' he added.
 
Lacruz commented: “The benefits of fluoride for oral health considerably outweigh the risks. But given how common dental fluorosis is and how poorly understood the cellular mechanisms responsible for this disease are, it is important to study this problem.” 

“If your cells have to make enamel, which is heavily calcified, and due to exposure to too much fluoride the cells undergo continued stress in their capacity to handle calcium, that will be reflected in the enamel crystals as they are formed and will impact mineralization,” Lacruz added.

The researchers repeated the experiment using early-stage kidney cells from humans, but they did not observe the same effects when the kidney cells were exposed to fluoride—suggesting that enamel cells are different from cells forming tissue in other parts of the body.

Fluoride is a naturally occurring mineral that helps to prevent cavities by promoting mineralization and making tooth enamel more resistant to acid. The Centers for Disease Control and Prevention (CDC) named water fluoridation one of 10 great public health achievements of the 20th century for its role in reducing tooth decay. 

While low levels of fluoride help strengthen and protect tooth enamel, too much fluoride can cause dental fluorosis—a discoloration of teeth, usually with opaque white marks, lines, or mottled enamel. Dental fluorosis occurs when children between birth and around nine years of age are exposed to high levels fluoride during this critical window when their teeth are forming, and can actually increase their risk of tooth decay. 



Posted by : GoDubai Editorial Team
Viewed 4572 times
Posted on : Tuesday, April 7, 2020  
Replication or redistribution in whole or in part is expressly prohibited without the prior written consent of GoDubai.com.
Previous Story : NYU Abu Dhabi Students Launch Where is Our Home?, A Storybook for Refugee Children
Next Story : NYU Abu Dhabi Researchers Synthesize Gold Nanoparticles Capable of Attacking Cancer Cells
Email this article Print this article

Share this article with your friends and followers
NewsVine

Comments

Back to Top  
Most Viewed Press Release posted in the last 7 days
HONOR MagicBook Series is Perfect for Fashion Forward, Design Conscious Individu...
Vatika Launches Natural Hair Food, an Effective Solution for Dry Hair
Omega Announces Its Role as the Official Timekeeper of the 36th America's Cup
Foreo Reveals 5 Ways to De-Stress Your Skin
DTTAG New Executive Committee to Manage Post Covid 19 Return to Normalcy of Travel
The Best Omega Sunglasses For a Long-Awaited Summer
Emirates Post Unveils Modern New Website and Look
Ethical JLT Salon THT is Supporting those whose Jobs have been affected during ...
Urgent Implementation of ICAO COVID-19 Guidelines Needed
FEM Collaborates with Arab Comedian Maya Acra to Address the Taboo Around the To...
Sony Middle East & Africa Introduces New Digital Camera ZV-1, designed for Vlogg...
Karl Lagereld Drives Digital Innovation With Launch of the “Maison Karl Lagerfe...
Innovating to Fight COVID-19: Four Ways Drones are Contributing
Blue Ocean for Islamic Finance Industry
Commodity Weekly: Crude Oil Frets Geopolitics, Sluggish Demand Bounce
Ericsson's USA 5G Factory: Staffed by Professionals – Trained by VR
Airline Debt to Balloon by 28%
The Ultimate At-Home Facial
Twentieth “World Milk Day” Sees NFPC Innovate With New Products That Meet Changi...
Parmigiani Fleurier Toric Fleur
Al Tayer Motors and Premier Motors Honour UAE's COVID-19 Frontline Heroes
80th Anniversary of Maserati's Targa Florio Victory Maserati Tests an Mc20 Proto...
Sony Middle East and Africa and Gearbox team up to offer rental services of late...
WTTC Launches Safe Travels Protocols for Aviation, Airports, MICE and Tour Operators
Tips for Keeping Your Smartphone Clean
Al-Futtaim Technologies Implements Genesys Remote Working Solutions to Ensure Bu...
SEHA Develops Cutting Edge Self-sterilization System for Ambulances
The Legend Continues: Xiaomi Unveils Redmi Note 9 Pro and Redmi Note 9
Telenor, Sony and Ericsson Team to Develop Smart IoT Healthcare Devices
ATM Virtual to Focus on Potential Chinese Outbound Travel Market
Lincoln Aviator Presidential Takes on Bumps and Dips, Turning Every Trip into a ...
Increasing Use of Screen-Time Causing Eye Problems in UAE Students
Salvatore Ferragamo Launches New Eyewear Styles Inspired by the Iconic Vara Bow
Etihad Airways Launches Health and Hygiene Programme Championed by New Wellness ...
Kleindienst Group's Floating Seahorse Villas Are Setting Sail to Welcome Guests ...
Danube Group Chairman Files Case With Dubai Police Against Scam Star for Faking ...
Honeywell Announces Opening of Gas Detector Factory in Saudi Arabia
ATM Virtual Panel Advises Hoteliers not to Drop Room Rates, but to Focus on Sani...
Kingston Technology Ships 7.68TB Capacity for Industry-Leading High-Performance ...
Philips Foundation and Philips Middle East Join Forces with Lebanese Red Cross t...
A Taste of Tradition
How to Improve Your Sleep Routine When Working From Home
GEMS Innovation Awards 2020 Recognise Young Innovators after Virtual Showdown
Dubai's Contemporary Art Institution Jameel Arts Centre re-opens to the Public
Al Majid Motors Announces the Arrival of All-New Kia K5 Fastback Sedan in the UAE
Former UNWTO Secretary-General to speak at ATM Virtual
DGW holds meeting to review updated strategic plan aimed at supporting national ...
Debut Arabian Travel Market Virtual Event gets Underway Tomorrow
Glaucoma: Symptoms and Treatment
Ras Al Khaimah Government Launches Integrated Stimulus Package to Support the Em...